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Our research group focuses on advancing knowledge of structure-function relationships in enzymes to facilitate enzyme modification for specific purposes. Enzyme modification is a growing field in response to policies promoting environmentally friendly catalysts. Our approach involves combinatorial mutagenesis of enzyme active sites, selecting enzymes through accelerated evolution, and characterizing them using kinetic and structural analyses, as well as computer-assisted molecular modeling. Our work also aims to better understand enzyme-induced drug resistance in the health sciences sector. Our interdisciplinary work in bio-organic chemistry, biochemistry, and bioinformatics contributes to the development of modern enzymology.